I'm at 430 with Sport 500's and most breather mods. I think with 3" exhaust I'd probably be close to the 450 you're looking for. I'm getting tuned for E85 this weekend; and I plan on using the stock fuel pump with 755CC injectors. My research indicates that ~500whp with E85 will be within the fuel pump and injectors capability. There are plenty of tuning options from a dedicated E85 chip to a map switcher, to a full flex fuel setup. I plan on manually swapping maps between 93oct and E85 with my Nistune laptop. I'd suggest doing a whole buttload of research. I spent a month or so going down a bunch of rabbit holes before I set out on my path.
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